Does left atrial volume affect exercise capacity of heart transplant recipients?

作者:Abdul Waheed Mohammad; Yousuf Mian; Kelly Stephanie J; Arena Ross; Ying Jun; Naz Tehmina; Dunlap Stephanie H; Shizukuda Yukitaka*
来源:Journal of Cardiothoracic Surgery, 2010, 5: 113.
DOI:10.1186/1749-8090-5-113

摘要

Background: Heart transplant (HT) recipients demonstrate limited exercise capacity compared to normal patients, very likely for multiple reasons. In this study we hypothesized that left atrial volume (LAV), which is known to predict exercise capacity in patients with various cardiac pathologies including heart failure and hypertrophic cardiomyopathy is associated with limited exercise capacity of HT recipients.
Methods: We analyzed 50 patients [age 57 +/-2 (SEM), 12 females] who had a post-HT echocardiography and cardiopulmonary exercise test (CPX) within 9 weeks time at clinic follow up. The change in LAV (Delta LAV) was also computed as the difference in LAV from the preceding one-year to the study echocardiogram. Correlations among the measured parameters were assessed with a Pearson's correlation analysis.
Results: LAV (n = 50) and Delta LAV (n = 40) indexed to body surface area were 40.6 +/- 11.5 ml.m(-2) and 1.9 +/- 8.5 ml.m (2)year (1), data are mean +/- SD, respectively. Indexed LAV and Delta LAV were both significantly correlated with the ventilatory efficiency, assessed by the VE/VCO(2) slope (r = 0.300, p = 0.038; r = 0.484, p = 0.002, respectively). LAV showed a significant correlation with peak oxygen consumption (r = -0.328, p = 0.020).
Conclusions: Although our study is limited by a retrospective study design and relatively small number of patients, our findings suggest that enlarged LAV and increasing change in LAV is associated with the diminished exercise capacity in HT recipients and warrants further investigation to better elucidate this relationship.

  • 出版日期2010-11-17