Determination of glomerular filtration rate (GFR) from fractional renal accumulation of iodinated contrast material: a convenient and rapid single-kidney CT-GFR technique

作者：Yuan, XiaoDong^*; Tang, Wei; Shi, WenWei; Yu, Libao; Zhang, Jing; Yuan, Qing; You, Shan; Wu, Ning; Ao, Guokun; Ma, Tingting

来源：European Radiology, 2018, 28(7): 2763-2771.

DOI：10.1007/s00330-017-5289-7

• Tomography
• X-ray computed
• Glomerular filtration rate
• Radioisotope renography
• Prospective studies
• Humans

To develop a convenient and rapid single-kidney CT-GFR technique. @@@ One hundred and twelve patients referred for multiphasic renal CT and 99mTc-DTPA renal dynamic imaging Gates-GFR measurement were prospectively included and randomly divided into two groups of 56 patients each: the training group and the validation group. On the basis of the nephrographic phase images, the fractional renal accumulation (FRA) was calculated and correlated with the Gates-GFR in the training group. From this correlation a formula was derived for single-kidney CT-GFR calculation, which was validated by a paired t test and linear regression analysis with the single-kidney Gates-GFR in the validation group. @@@ In the training group, the FRA (x-axis) correlated well (r = 0.95, p < 0.001) with single-kidney Gates-GFR (y-axis), producing a regression equation of y = 1665x + 1.5 for single-kidney CT-GFR calculation. In the validation group, the difference between the methods of single-kidney GFR measurements was 0.38 +/- 5.57 mL/min (p = 0.471); the regression line is identical to the diagonal (intercept = 0 and slope = 1) (p = 0.727 and p = 0.473, respectively), with a standard deviation of residuals of 5.56 mL/min. @@@ A convenient and rapid single-kidney CT-GFR technique was presented and validated in this investigation. @@@ The new CT-GFR method takes about 2.5 min of patient time. @@@ The CT-GFR method demonstrated identical results to the Gates-GFR method. @@@ The CT-GFR method is based on the fractional renal accumulation of iodinated CM. @@@ The CT-GFR method is achieved without additional radiation dose to the patient.

• 出版日期2018-7
• 单位中国人民解放军第三〇九医院; 复旦大学