A potential function for neuronal exosomes: Sequestering intracerebral amyloid-beta peptide

作者：Yuyama Kohei^*; Sun Hui; Usuki Seigo; Sakai Shota; Hanamatsu Hisatoshi; Mioka Tetsuo; Kimura Nobuyuki; Okada Megumi; Tahara Hidetoshi; Furukawa Jun ichi; Fujitani Naoki; Shinohara Yasuro; Igarashi Yasuyuki

来源：FEBS LETTERS, 2015, 589(1): 84-88.

DOI：10.1016/j.febslet.2014.11.027

• Exosome
• Amyloid-beta peptide
• Alzheimer's disease
• Cynomolgus monkey
• APP transgenic mouse
• Cerebrospinal fluid

Elevated amyloid-beta peptide (A beta) in brain contributes to Alzheimer's disease (AD) pathogenesis. We demonstrated the presence of exosome-associated A beta in the cerebrospinal fluid (CSF) of cynomolgus monkeys and APP transgenic mice. The levels of exosome-associated A beta notably decreased in the CSF of aging animals. We also determined that neuronal exosomes, but not glial exosomes, had abundant glycosphingolipids and could capture A beta. Infusion of neuronal exosomes into brains of APP transgenic mice decreased A beta and amyloid depositions, similarly to what reported previously on neuroblastoma-derived exosomes. These findings highlight the role of neuronal exosomes in A beta clearance, and suggest that their downregulation might relate to Ab accumulation and, ultimately, the development of AD pathology.

• 出版日期2015-1-2
• 单位河北医科大学