Using Drinking in the Dark to model prenatal binge-like exposure to ethanol in C57BL/6J mice

作者：Boehm Stephen L II^*; Moore Eileen M; Walsh Cherie D; Gross Carly D; Cavelli Austin M; Gigante Eduardo; Linsenbardt David N

来源：Developmental Psychobiology, 2008, 50(6): 566-578.

DOI：10.1002/dev.20320

• in utero
• binge
• ethanol
• intake
• behavior
• mouse
• Drinking in the Dark

Animal models of prenatal ethanol exposure are necessary to more fully understand the effects of ethanol on the developing embryo/fetus. However, most models employ procedures that may produce additional maternal stress beyond that produced by ethanol alone. We employed a daily limited-access ethanol intake model called Drinking in the Dark (DID) to assess the effects of voluntary maternal binge-like ethanol intake on the developing mouse. Evidence suggests that binge exposure may be particularly harmful to the embryol/fetus, perhaps due to the relatively higher blood ethanol concentrations achieved. pregnant females had mean daily ethanol intakes ranging from 4.2 to 6.4 g/kg ethanol over gestation, producing blood ethanol concentrations ranging from 115 to 182 mg/dL. This level of ethanol intake produced behavioral alterations among adolescent offspring that disappeared by adulthood, including altered sensitivity to ethanol's hypnotic actions. The DID model may provide a useful tool for studying the effects of prenatal ethanol exposure in mice.

• 出版日期2008-9