Modified SBA-15 as the carrier for metoprolol and papaverine: Adsorption and release study

作者：Moritz Michai; Laniecki Marek^*

来源：Journal of Solid State Chemistry, 2011, 184(7): 1761-1767.

DOI：10.1016/j.jssc.2011.05.015

• Modified SBA-15
• Metoprolol
• Papaverine
• (3-mercapropropyl)trimethoxysilane

A series of modified SBA-15 materials were applied in drug delivery systems. The internal surface of siliceous hexagonal structure of SBA-15 was modified with different amount of (3-mercaptopropyl)-trimethoxysilane (MPTMS) and oxidized in the presence of hydrogen peroxide. The sulfonated material was loaded with metoprolol tartrate or papaverine hydrochloride. Both drugs indicated strong chemical interaction with modified mesoporous surface. The characteristic of the obtained materials was performed with XRD and DRUV-vis spectrometry, themogravimetry and nitrogen adsorption (BET) measurements. The obtained results show that modification of the mesoporous materials leads towards significant decrease of the drug delivery rate.

• 出版日期2011-7