Complete Sequence of Broad-Host-Range Plasmid pRIO-5 Harboring the Extended-Spectrum-beta-Lactamase Gene bla(BES-1)

作者：Bonnin Remy A; Poirel Laurent; Mello Sampaio Jorge Luiz; Nordmann Patrice^*

来源：Antimicrobial Agents and Chemotherapy, 2012, 56(2): 1116-1119.

DOI：10.1128/AAC.00480-11

Broad-host-range plasmid pRIO-5, harboring the extended-spectrum beta-lactamase bla(BES-1) gene in Serratia marcescens, was fully sequenced. Analysis of the 12,957-bp sequence of this IncP6-type plasmid revealed that the bla(BES-1) gene was associated with two copies of the insertion sequence IS26. The promoter responsible for the bla(BES-1) expression was hybrid, made of a - 35 box located inside the inverted repeat of IS26 and a - 10 box inside a remnant of an insertion sequence.

• 出版日期2012-2