Prolonged First-Dose Hypotension Induced by Sacubitril/Valsartan

作者：Hsiao Fu-Chih; Chu Pao-Hsien^*

来源：Acta Cardiologica Sinica, 2018, 34(1): 96-98.

DOI：10.6515/AC5.201801_34(1).20170614A

• First dose
• Hypotension
• Sacubitril/valsartan

Entresto was recommanded by major guidelines as the frontline therapy for heart failure with reduced ejection fraction since its clinical benefit was proved by the PARADIGM-HF trial. Angiotensin converting enzyme inhibitors are the cornerstone of the treatment of HF. Varying incidences of first-dose hypotension have been reported and recognized as a potential limiting factor for prescribing. According to previous reports, the onset of hypotension mostly occur 3-5 hours after the first dose. However, the pattern of entresto-related hypotension has not been reported. We present a case of HF, who had delay onset (about 8 to 18 hours) and prolonged (3 to 6 days) first-dose hypotension. Further investigation is required to illustrate this phenomenon.

• 出版日期2018-1
• 单位长春大学