科研之友
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摘要
A protocol for the introduction of spiro[4.5] lactone straps onto the Troger's base scaffold has been developed. The conversion was found to be most efficient when an appropriate carboxylic acid derivative reacted with 5,6,11,12-tetrahydrodibenzo[b,f][1,5]diazocines. Whilst phthaloyl dichloride was the main strap-forming precursor used, other 1,2-unsaturated dicarboxylic acids could be used in the presence of N,N-dicyclohexylcarbodiimide.
- 出版日期2009-2-16
