Antidiabetic Properties, Bioactive Constituents, and Other Therapeutic Effects of Scoparia dulcis

作者：Pamunuwa Geethi; Karunaratne D Nedra; Waisundara Viduranga Y

来源：Evidence-Based Complementary and Alternative Medicine, 2016, 2016: 8243215.

DOI：10.1155/2016/8243215

<jats:p>This review discusses the antidiabetic activities of<jats:italic>Scoparia dulcis</jats:italic>as well as its antioxidant and anti-inflammatory properties in relation to the diabetes and its complications. Ethnomedical applications of the herb have been identified as treatment for jaundice, stomach problems, skin disease, fever, and kidney stones, reproductory issues, and piles. Evidence has been demonstrated through scientific studies as to the antidiabetic effects of crude extracts of<jats:italic>S. dulcis</jats:italic>as well as its bioactive constituents. The primary mechanisms of action of antidiabetic activity of the plant and its bioactive constituents are through<jats:italic>α</jats:italic>-glucosidase inhibition, curbing of PPAR-<jats:italic>γ</jats:italic>and increased secretion of insulin. Scoparic acid A, scoparic acid D, scutellarein, apigenin, luteolin, coixol, and glutinol are some of the compounds which have been identified as responsible for these mechanisms of action.<jats:italic>S. dulcis</jats:italic>has also been shown to exhibit analgesic, antimalarial, hepatoprotective, sedative, hypnotic, antiulcer, antisickling, and antimicrobial activities. Given this evidence, it may be concluded that<jats:italic>S. dulcis</jats:italic>could be promoted among the masses as an alternative and complementary therapy for diabetes, provided further scientific studies on the toxicological and pharmacological aspects are carried out through either<jats:italic>in vivo</jats:italic>or clinical means.</jats:p>

• 出版日期2016