Novel male exposure reduces uterine e-cadherin, increases uterine luminal area, and diminishes progesterone levels while disrupting blastocyst implantation in inseminated mice

作者：Rajabi Nazanin; Thorpe Joelle B; Foster Warren G; deCatanzaro Denys^*

来源：Journal of Steroid Biochemistry and Molecular Biology, 2014, 139: 107-113.

DOI：10.1016/j.jsbmb.2013.08.005

• Implantation
• Blastocyst
• E-cadherin
• Uterus
• Luminal closure
• Progesterone

Exposure to novel male mice disrupts blastocyst implantation in inseminated female mice, and evidence increasingly implicates the female's absorption of male urinary estrogens. We observed implantation sites in male-exposed and isolated control female mice during gestation days (GD) 2-8, observing a significant reduction in male-exposed females compared to controls, particularly on GD 6 and 8. We also measured transitions in uterine luminal area and e-cadherin expression, as these processes are modulated by estrogens. Luminal area was greater in male-exposed females than in controls during the post-implantation period (GD 5-7). E-cadherin levels were suppressed by male exposure, particularly during GD 4-6 Serum progesterone levels were also reduced in male-exposed females. The effects of male exposure on uterine closure and e-cadherin levels are consistent with established effects of estrogens, and suggest a possible mechanism that could contribute to implantation failure.
This article is part of a Special Issue entitled 'Pregnancy and Steroids'.

• 出版日期2014-1