Noradrenaline is a stress-associated metaplastic signal at GABA synapses

作者：Inoue Wataru; Baimoukhametova Dinara V; Fuezesi Tamas; Wamsteeker Cusulin Jaclyn I; Koblinger Kathrin; Whelan Patrick J; Pittman Quentin J; Bains Jaideep S^*

来源：Nature Neuroscience, 2013, 16(5): 605-+.

DOI：10.1038/nn.3373

Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypothalamus in rat and mouse that controls the hypothalamic-pituitary-adrenal axis. In vivo stress exposure was required for these synapses to undergo activity-dependent long-term potentiation (LTPGABA). The activation of beta-adrenergic receptors during stress functionally upregulated metabotropic glutamate receptor 1 (mGluR1), allowing for mGluR1-dependent LTPGABA during afferent bursts. LTPGABA was expressed postsynaptically and manifested as the emergence of new functional synapses. Our findings provide, to the best of our knowledge, the first demonstration that noradrenaline release during an in vivo challenge alters information storage capacity at GABA synapses. Because these GABA synapses become excitatory following acute stress, this metaplasticity may contribute to neuroendocrine sensitization to stress.

• 出版日期2013-5