Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia

作者：Fornace Kimberly M^*; Nuin Nor Afizah; Betson Martha; Grigg Matthew J; William Timothy; Anstey Nicholas M; Yeo Tsin W; Cox Jonathan; Ying Lau Tiek; Drakeley Chris J

来源：Journal of Infectious Diseases, 2016, 213(5): 784-787.

DOI：10.1093/infdis/jiv475

• malaria
• Plasmodium knowlesi
• submicroscopic infection
• asymptomatic parasitemia

Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

• 出版日期2016-3-1