SOD1 Plasma Level as a Biomarker for Therapeutic Failure in Cutaneous Leishmaniasis

作者：Khouri Ricardo; Santos Gilvaneia Silva; Soares George; Costa Jackson M; Barral Aldina; Barral Netto Manoel; Van Weyenbergh Johan^*

来源：Journal of Infectious Diseases, 2014, 210(2): 306-310.

DOI：10.1093/infdis/jiu087

• Cutaneous leishmaniasis
• Leishmania amazonensis
• Leishmania braziliensis
• Diffuse cutaneous leishmaniasis
• Oxidative burst
• Parasite escape mechanism
• Interkingdom signaling
• Superoxide dismutase
• Biomarker
• Therapeutic failure

We show that increased plasma superoxide dismutase 1 (SOD1) levels are statistically significant predictors of the failure of pentavalent antimony treatment for cutaneous leishmaniasis caused by Leishmania braziliensis. In Leishmania amazonensis-infected patients, host SOD1 levels can be used to discriminate between localized and drug-resistant diffuse cutaneous leishmaniasis. Using in situ transcriptomics (nCounter), we demonstrate a significant positive correlation between host SOD1 and interferon alpha/beta messenger RNA (mRNA) levels, as well as interkingdom correlation between host SOD1 and parasite SOD2/4 mRNA levels. In human macrophages, in vitro treatment with SOD1 increases the parasite burden and induces a diffuse cutaneous leishmaniasis-like morphology. Thus, SOD1 is a clinically relevant biomarker and a therapeutic target in both localized and diffuse cutaneous leishmaniasis.

• 出版日期2014-7-15
• 单位KU Leuven; 河北医科大学