Adeno-associated virus-mediated cancer gene therapy: Current status

作者：Luo, Jingfeng; Luo, Yuxuan; Sun, Jihong; Zhou, Yurong; Zhang, Yajing; Yang, Xiaoming^*

来源：Cancer Letters, 2015, 356(2): 347-356.

DOI：10.1016/j.canlet.2014.10.045

• Adeno-associated virus
• Cancer
• Cancer gene therapy
• Gene vehicle

Gene therapy is one of the frontiers of modern medicine. Adeno-associated virus (AAV)-mediated gene therapy is becoming a promising approach to treat a variety of diseases and cancers. AAV-mediated cancer gene therapies have rapidly advanced due to their superiority to other gene-carrying vectors, such as the lack of pathogenicity, the ability to transfect both dividing and non-dividing cells, low host immune response, and long-term expression. This article reviews and provides up to date knowledge on AAV-mediated cancer gene therapy. Published by Elsevier Ireland Ltd.

• 出版日期2015-1-28
• 单位浙江大学