A supramolecular DNA self-assembly based on beta-cyclodextrin-adamantane complexation as a bioorthogonal sticky end motif

作者:Chiba Junya*; Sakai Ayumi; Yamada Syogo; Fujimoto Kazuhisa; Inouye Masahiko
来源:Chemical Communications, 2013, 49(57): 6454-6456.
DOI:10.1039/c3cc43109f

摘要

We propose linear end-to-end assemblies of short DNA duplexes based on beta-cyclodextrin-adamantane complexation. The assembled duplexes exhibited increased T-m values compared with those of the corresponding natural hybrids. Competition experiments with external guest molecules showed a substantial decrease in T-m of the terminal modified duplexes, suggesting the viability of inter-duplex complexation.

  • 出版日期2013