Anti-oncogenic potential of the eIF4E-binding proteins

作者：Martineau Y; Azar R; Bousquet C; Pyronnet S^*

来源：Oncogene, 2013, 32(6): 671-677.

DOI：10.1038/onc.2012.116

• protein synthesis
• elF4E
• 4E-BP
• mTOR

The elF4E-binding proteins (4E-BPs) are inhibitors of protein synthesis that sequester the mRNA cap-binding protein elF4E and consequently block cell growth and proliferation. In most tumors however, their inhibitory function is compromised by major oncogenic signaling pathways. Recently, thanks to the generation of mouse genetic models, considerable progress has been made in elucidating the involvement of 4E-BPs and their unique target, elF4E, in the process of carcinogenesis. Increasing evidence indicates that an 'addiction' to protein synthesis emerges in cancer cells, highlighting the potential that 4E-BPs have as targets for therapeutics. In this review, we summarize the biochemical function, regulation and anti-oncogenic activity of the 4E-BPs. Oncogene (2013) 32, 671-677; doi:10.1038/onc.2012.116; published online 16 April 2012

• 出版日期2013-2-7