Amino acid sensing by mTORC1, a new pathway involved in metabolism and cancer

作者：Giorgetti Peraldi Sophie^*; Peraldi Pascal; Dumas Karine; Pastor Faustine; Tanti Jean Francois

来源：Correspondances en Metabolismes Hormones Diabetes et Nutrition, 2016, 20(10): 300-305.

• mTORC1
• Amino acid
• Cancer
• Metabolism

mTORC1 plays a crucial role to adapt metabolism to environmental conditions, such as nutrients and growth factors.
mTORC1 activation in response to growth factors and amino acids requires distinct signaling pathways.
Mutations affecting amino acids sensing are involved in pathologies such as cancer, primary immunodeficience syndrome and Birt-Hogg-Dube syndrome

• 出版日期2016-12