Application of computed tomography images in the evaluation of magnetic nanoparticles biodistribution

作者：Dias Argleydson Leao; Kunzel Roseli^*; Levenhagen Ronaldo Savarino; Okuno Emico

来源：Journal of Magnetism and Magnetic Materials, 2010, 322(16): 2405-2407.

DOI：10.1016/j.jmmm.2010.02.046

• Magnetic nanoparticle
• Computed tomography
• Imaging contrast
• Iodine

In this work we evaluate the effectiveness of computed tomography images as a tool to determine magnetic nanoparticle biodistribution over biological tissues. For this purpose, tomography images for magnetic nanoparticles, composed of Fe(3)O(4), coated with 2,3-dimercaptosuccinic acid (DMSA), were generated at several material concentrations. The comparison of CT numbers, calculated from these images generated at clinical conditions, with typical CT numbers for biological tissues, shows that the detection of nanoparticle in most tissues is only possible for high material concentrations.

• 出版日期2010-8