Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization

作者：Bloom Michael S^*; Kim Dongsul; vom Saal Frederick S; Taylor Julia A; Cheng Gloria; Lamb Julie D; Fujimoto Victor Y

来源：Fertility and Sterility, 2011, 96(3): 672-U199.

DOI：10.1016/j.fertnstert.2011.06.063

• Bisphenol A (BPA)
• estradiol (E(2))
• follicle
• in vitro fertilization (IVF)
• ovary

Objective: To investigate associations between serum bisphenol A (BPA) concentrations and follicular response to exogenous ovary stimulation.
Design: Fasting serum was prospectively collected on the day of oocyte retrieval and assessed for unconjugated BPA using high-performance liquid chromatography with Coularray detection. Multivariable linear regression and negative binomial regression were used to assess associations between concentrations of BPA and outcome measures. Models were adjusted for race/ethnicity, antral follicle count at baseline, and cigarette smoking.
Setting: A reproductive health center.
Patient(s): Forty-four women undergoing IVF.
Intervention(s): None.
Main Outcome Measure(s): Peak E(2) level and the number of oocytes retrieved during IVF.
Result(s): The median unconjugated serum BPA concentration is 2.53 ng/mL (range = 0.3-67.36 ng/mL). Bisphenol A is inversely associated with E(2) (beta = -0.16; 95% confidence interval = -0.32, 0.01), as well as with E(2) normalized to the number of mature-sized follicles at the hCG trigger (beta = -0.14; 95% confidence interval = -0.24, -0.03). No association is observed for BPA and the number of oocytes retrieved (adjusted risk ratio = 0.95; 95% confidence interval = 0.82, 1.10).
Conclusion(s): Bisphenol A is associated with a reduced E(2) response during IVF. Although limited by the preliminary nature of this study, these results merit confirmation in a future comprehensive investigation. (Fertil Steril (R) 2011;96: 672-7.

• 出版日期2011-9