New Application of F-18-Fluoride PET for the Detection of Bone Remodeling in Early-Stage Osteoarthritis of the Hip

作者：Kobayashi Naomi^*; Inaba Yutaka; Tateishi Ukihide; Yukizawa Yohei; Ike Hiroyuki; Inoue Tomio; Saito Tomoyuki

来源：Clinical Nuclear Medicine, 2013, 38(10): E379-E383.

• osteoarthritis of the hip
• PET
• fluoride
• imaging diagnosis

Purpose: Recent studies have reported the acceleration of subchondral bone remodeling during the development of osteoarthritis (OA). However, it is not possible to evaluate such molecular abnormalities using conventional radiographic techniques. We have applied F-18-fluoride PET to the analysis of painful or dysplastic hips at various stages of OA and then compared this with radiographic findings and clinical findings. %26lt;br%26gt;Methods: A consecutive series of 65 joints from 48 patients (average age, 40 years; range, 19Y72 years) with a hip joint complaint or radiographic dysplastic hip were enrolled in this study. Twenty-five contralateral joints without any evidence of OA or clinical symptoms were assigned as a normal control group. Radiographic evaluations were performed on the basis of Kellgren and Lawrence grade and the minimum joint space. Clinical evaluations were performed using the grading scale for pain severity and the SUVmax was measured for each joint. The association between SUVmax and the radiographic or clinical findings was evaluated. %26lt;br%26gt;Results: F-18-fluoride PET shows a significantly higher uptake value for progressive-stage OA cases than for early-stage cases and also shows a significantly higher uptake value in cases with severe pain. Even in early-OAstage patients who do not show joint space narrowing on a plain x-ray, cases with severe pain show a significantly higher uptake value. %26lt;br%26gt;Conclusions: F-18-fluoride PET has great potential as an imaging method for diagnosing early-stage OA without any marked radiographic changes.

• 出版日期2013-10