Aminopeptidase N/CD13 targeting fluorescent probes: Synthesis and application to tumor cell imaging

作者：Zhang Z; Harada H; Tanabe K; Hatta H; Hiraoka M; Nishimoto S^*

来源：Peptides, 2005, 26(11): 2182-2187.

DOI：10.1016/j.peptides.2005.03.049

• aminopeptidase N (APN/CD13)
• tumor-homing peptide
• CNGRC
• fluorescent probe
• molecular imaging

A family of fluorescein-peptide conjugates (CNP1-3) for aminopeptidase N (APN/CD13) targeting fluorescent probes were designed and synthesized. Among the three conjugates, CNP1 bearing tumor-homing cyclic peptide CNGRC, could selectively label APN/CD13 over-expressing on the surface of tumor cells of HT-1080, as identified by means of fluorescent microscopic cell imaging. CNP1 was shown to be a promising fluorescent probe applicable to tumor-targeting molecular imaging.

• 出版日期2005-11