Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon

作者：Dias G A S^*; Yoshikawa G T; Koyama R V L; Fujihara S; Martins L C S; Medeiros R; Quaresma J A S; Fuzii H T

来源：Spinal Cord, 2016, 54(2): 154-157.

DOI：10.1038/sc.2015.112

Study design: A cross-sectional observational study was conducted.
Objective: The aim was to analyze the clinical-functional profile of patients diagnosed with HTLV-1 (human T-lymphotropic virus type 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in the Amazon region.
Setting: Reference center for HTLV in the city of Belem, state of Para, Brazil.
Methods: Muscle strength, muscle tone, balance and the need for gait assistance among patients with HAM/TSP were evaluated.
Results: Among the 82 patients infected with HTLV-1, 27 (10 men and 17 women) were diagnosed with HAM/TSP. No statistically significant difference in muscle tone or strength was found between the lower limbs. Muscle weakness and spasticity were predominant in the proximal lower limbs. Patients with HAM/TSP are at a high risk of falls (P=0.03), and predominantly use either a cane or a crutch on one side as a gait-assistance device (P=0.02).
Conclusion: Patients with HAM/TSP exhibit a similar clinical pattern of muscle weakness and spasticity, with a high risk of falls, requiring gait-assistance devices.

• 出版日期2016-2