A Portable Low-Power Acquisition System with a Urease Bioelectrochemical Sensor for Potentiometric Detection of Urea Concentrations

作者：Ma, Wei-Jhe; Luo, Ching-Hsing^*; Lin, Jiun-Ling; Chou, Sin-Houng; Chen, Ping-Hung; Syu, Mei-Jywan; Kuo, Shin-Hung; Lai, Shin-Chi

来源：Sensors (Switzerland), 2016, 16(4): 474.

DOI：10.3390/s16040474

• portable
• battery-driven
• bioelectrochemical signal acquisition
• urea
• potentiometric
• immobilized urease
• MEMS

This paper presents a portable low-power battery-driven bioelectrochemical signal acquisition system for urea detection. The proposed design has several advantages, including high performance, low cost, low-power consumption, and high portability. A LT1789-1 low-supply-voltage instrumentation amplifier (IA) was used to measure and amplify the open-circuit potential (OCP) between the working and reference electrodes. An MSP430 micro-controller was programmed to process and transduce the signals to the custom-developed software by ZigBee RF module in wireless mode and UART in able mode. The immobilized urease sensor was prepared by embedding urease into the polymer (aniline-co-o-phenylenediamine) polymeric matrix and then coating/depositing it onto a MEMS-fabricated Au working electrode. The linear correlation established between the urea concentration and the potentiometric change is in the urea concentrations range of 3.16 x 10(-4) to 3.16 x 10(-2) M with a sensitivity of 31.12 mV/log [M] and a precision of 0.995 (R-2 = 0.995). This portable device not only detects urea concentrations, but can also operate continuously with a 3.7 V rechargeab-le lithium-ion battery (500 mA.h) for at least four days. Accordingly, its use is feasible and even promising for home-care applications.

• 出版日期2016-4
• 单位河北医科大学; 中山大学