Deep Brain Recordings Using an Implanted Pulse Generator in Parkinson's Disease

作者：Neumann Wolf Julian; Staub Franziska; Horn Andreas; Schanda Julia; Mueller Joerg; Schneider Gerd Helge; Brown Peter; Kuehn Andrea A

来源：Neuromodulation, 2016, 19(1): 20-23.

DOI：10.1111/ner.12348

• Basal ganglia
• beta oscillations
• deep brain stimulation
• local field potentials
• subthalamic nucleus

Objectives: Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with Parkinson's disease for subthalamic closed-loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator.
Methods: Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation (DBS). All data were analyzed in the frequency domain using Fourier transform-based methods and compared between ON and OFF stimulation conditions.
Results: Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity (p = 0.002).
Conclusion: The results of the study suggest that oscillatory beta band synchronization and its modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed-loop stimulation in patients with Parkinson's disease.

• 出版日期2016-1