New Ce(III) Complex Compounds of 2-(N,N-dimethylbiguanidil)-penta-1,5-dioic Acid with Biological Activity

作者：Negreanu Pirjol Ticuta; Negreanu Pirjol Bogdan^*; Sirbu Rodica; Paris Stelian; Giurginca Maria; Guran Cornelia; Cristescu Tudora

来源：Revista de Chimie, 2014, 65(8): 986-992.

• Ce(III) complex compounds
• 2-(N,N-dimethylbiguanidil)-penta-1,5-dioic acid
• biological activity

The paper present the biological properties, total antioxidant capacity and antimicrobial activity against different Gram positive and Gram negative strains and fungi, of some new Ce(III) complex compounds with Schiff base as ligands; the ligands were obtained by condensation between a-ketoglutaric acid and N,N-dimethylbiguanide (base and hydrochloride), in well-established condition. The new synthesized ligands were obtained as hydrochloride salt (2-(N,N-dimethylbiguanidyl)-penta-1,5-dioic hydrochloride acid,L-1) and also in neutral form (2-(N,N-dimethylbiguanidyl)-penta-1,5-dioic acid, L-2); the new ligands and theirs Ce(III) complex compounds have been physico-chemically characterized by elemental chemical analysis, molar electrical conductivity, FT/IR, UV-Vis spectrometry and NMR. The surface of the ligands and complex compounds [Ce(L-2)(NO3)(3)(OH2)(4)] and [Ce(L-1)(NO3)(3)(O-H)(4)]HCl powders, were investigated in terms of morphology by optical microscopy reflection in the scan. The biological activity of new complex compounds [Ce(L-2)(NO3)(3)(OH2)(4)] and [Ce(L-1)(NO3)(3)(OH2)(4)]HCl, were L-1 = 2-(N,N-dimethylbiguanidil)-penta-1,5-dioic hydrochloride acid and L-2 = 2-(N,N-dimethylbiguanidil)-penta-1,5-dioic acid was increased compared to that of the new ligands and reactants used for synthesis.

• 出版日期2014-8