APLYSFISTULARINE: A NOVEL DIBROMOTYROSINE DERIVATIVE ISOLATED FROM Aplysina fistularis

作者：Lira Narlize Silva^*; Monte Neto Rubens L; Marchi Joao Guilherme B; da Silva Lins Antonio Claudio; Tavares Josean Fechine; da Silva Marcelo Sobral; Dias Celidarque da Silva; Barbosa Filho Jose Maria; dos Santos Creusioni Figueredo; Leitao da Cunha Emidio Vasconcelos; Pinheiro Ulisses dos Santos; Braz Filho Raimundo

来源：Quimica Nova, 2012, 35(11): 2189-2193.

DOI：10.1590/S0100-40422012001100017

• Aplysina fistularis
• aplysfistularine
• topoisomerase activity

The new dibromotyrosine derivative 3,5-dibromo-4-[3%26apos; dimethylamonium]propoxyphenyl]-N,N,N-trimethylethanamonium, here referred to as aplysfistularine (1), was isolated from the marine sponge Aplysina fistularis along with 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-trimethylethanamonium (2), aplysterol (3) and 24,28-didehydroaplysterol (4). Their identification was performed by mass spectrometry, infrared, H-1 and C-13 NMR, and by comparison with literature data. Compound 2 and the mixture of 3 and 4 were tested in vitro (inhibitory activity) with supercoiled DNA relaxation techniques, and showed inhibitory activity on human DNA topoisomerase II-alpha. Compound 1 was not tested due to paucity of the material.

• 出版日期2012