New strategies for the prevention of stroke

作者：Liu, Ai Jun; Guo, Jin Min; Xia, Weiliang; Su, Ding Feng^*

来源：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2010, 37(2): 265-271.

DOI：10.1111/j.1440-1681.2009.05230.x

• arterial baroreflex
• folic acid
• hypertension
• pro-inflammatory factor
• risk factor
• stroke prevention

1. Stroke is a major cause of disability and death worldwide. It is preferable to prevent stroke rather than to treat it and, for the prevention of stroke, all risk factors relating to stroke need to be understood. The present paper reviews potential new strategies for the prevention of stroke based on findings of new risk factors, as well as classical risk factors.
2. Recently, new risk factors related to stroke were reported, including dysfunction of the arterial baroreflex, pro-inflammatory cytokines, vitamins and hormone deficiency. Correspondingly, therapies targeting these risk factors where shown to significantly reduce the incidence and/or severity of stroke.
3. Because the genesis of stroke is multifactorial, the prevention of stroke should not target one risk factor only. Combination therapies with drugs acting on different risk factors may be more effective in the prevention of stroke.

• 出版日期2010-2
• 单位中国人民解放军第二军医大学; 上海交通大学