A comparative study of disintegration actions of various disintegrants using Kohonen's self-organizing maps

作者：Onuki Yoshinori^*; Kosugi Atsushi; Hamaguchi Masashi; Marumo Yuki; Kumada Shungo; Hirai Daijiro; Ikeda Junko; Hayashi Yoshihiro

来源：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2018, 43: 141-148.

DOI：10.1016/j.jddst.2017.10.002

• Tablet
• Disintegrant
• Self-organizing map
• Disintegration time
• Tensile strength
• Powder property

To gain a better understanding of disintegration actions, 11 different disintegrants were tested. Model tablets were prepared with various preparation conditions, and their disintegration time and tensile strength were measured. The present study also investigated various physicochemical properties of the model tablets and disintegrant powders, including wetting time, water absorption ratio, particle size, morphological observation, swelling property, and T-2 relaxation time (T-2). The experimental data were thoroughly analyzed using selforganizing map (SOM) clustering. The test disintegrants were classified into four distinct clusters. It is worth noting that superdisintegrants, including croscarmellose sodium (Ac-Di-Sol), sodium starch glycolate (Glycolys), and crospovidone (Kollidone CL-F and Polyplasdon XL-10), were assigned to clusters different from those of normal disintegrants. Furthermore, SOM clustering suggested the latent contributions of factors to the disintegration actions. The disintegrant content had a significant impact on the disintegration actions. Furthermore, the T-2 measurements indicated that the interaction mode of crospovidone with water was different from those of cellulose-and starch-based disintegrants. The evidence obtained is valuable information for the formulation design of tablets.

• 出版日期2018-2