Bone regeneration potential of a soybean-based filler: experimental study in a rabbit cancellous bone defects

作者：Giavaresi Gianluca; Fini Milena; Salvage Jonathan; Aldini Nicolo Nicoli; Giardino Roberto; Ambrosio Luigi; Nicolais Luigi; Santin Matteo^*

来源：Journal of Materials Science: Materials in Medicine , 2010, 21(2): 615-626.

DOI：10.1007/s10856-009-3870-6

Autologous and allogenic bone grafts are considered as materials of choice for bone reconstructive surgery, but limited availability, risks of transmittable diseases and inconsistent clinical performances have prompted the development of alternative biomaterials. The present work compares the bone regeneration potential of a soybean based bone filler (SB bone filler) in comparison to a commercial 50:50 poly(d,l lactide-glycolide)-based bone graft (Fisiograft(A (R)) gel) when implanted into a critical size defect (6-mm diameter, 10-mm length) in rabbit distal femurs. The histomorphometric and microhardness analyses of femoral condyles 4, 8, 16 and 24 weeks after surgery showed that no significant difference was found in the percentage of both bone repair and bone in-growth in the external, medium and inner defect areas. The SB filler-treated defects showed significantly higher outer bone formation and microhardness results at 24 weeks than Fisiograft(A (R)) gel (P < 0.05). Soybean-based biomaterials clearly promoted bone repair through a mechanism of action that is likely to involve both the scaffolding role of the biomaterial for osteoblasts and the induction of their differentiation.

• 出版日期2010-2