Analysis of high-dose rate brachytherapy dose distribution resemblance in CyberKnife hypofractionated treatment plans of localized prostate cancer

作者：Sudahar H^*; Kurup P G G; Murali V; Mahadev P; Velmurugan J

来源：Medical Dosimetry, 2013, 38(4): 385-389.

DOI：10.1016/j.meddos.2013.04.006

• Hypofractionation
• CyberKnife
• HDR brachytherapy
• Localized prostate

The present study is to analyze the CyberKnife hypofractionated dose distribution of localized prostate cancer in terms of high-dose rate (HDR) brachytherapy equivalent doses to assess the degree of HDR brachytherapy resemblance of CyberKnife dose distribution. Thirteen randomly selected localized prostate cancer cases treated using CyberKnife with a dose regimen of 36.25 Gy in 5 fractions were considered. HDR equivalent doses were calculated for 30 Gy in 3 fractions of HDR brachytherapy regimen. The D-5% of the target in the CyberKnife hypofractionation was 41.57 +/- 2.41 Gy. The corresponding HDR fractionation (3 fractions) equivalent dose was 32.81 +/- 1.86 Gy. The mean HDR fractionation equivalent dose, D-98%, was 27.93 +/- 0.84 Gy. The V-100% of the prostate target was 95.57% 3.47%. The V-100% of the bladder and the rectum were 717.16 and 79.6 mm(3), respectively. Analysis of the HDR equivalent dose of CyberKnife dose distribution indicates a comparable resemblance to HDR dose distribution in the peripheral target doses (D-98% to D-80%) reported in the literature. However, there is a substantial difference observed in the core high-dose regions especially in D-10% and D-5%. The dose fall-off within the OAR is also superior in reported HDR dose distribution than the HDR equivalent doses of CyberKnife.

• 出版日期2013