Anti-Saccharomyces cerevisiae antibodies in primary biliary cirrhosis

作者：Sakly Wahiba; Jeddi Moncef; Ghedira Ibtissem^*

来源：Digestive Diseases and Sciences, 2008, 53(7): 1983-1987.

DOI：10.1007/s10620-007-0092-y

• anti-Saccharomyces cerevisiae antibodies
• primary biliary cirrhosis
• anti-mitochondrial antibodies

Aim The aim of this study was to evaluate, retrospectively, the frequency of anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with primary biliary cirrhosis (PBC). Methods ASCA, IgG, and IgA, were determined by ELISA in sera of 95 PBC patients; 80 healthy blood donors served as controls. Results The frequency of ASCA (IgG or IgA) was significantly higher in PBC patients than in the control group (24.2% vs 3.7%, P = 0.0001). The frequency of ASCA IgG and ASCA IgA in PBC patients was also significantly higher than that found in the control group (18.9% vs 2.5%, P = 0.0006 and 11.6% vs 1.2%, P = 0.007, respectively). Six patients out of 95 (6.3%) had both ASCA IgG and ASCA IgA; in contrast, none of the control group had both isotypes (P = 0.02). There was no correlation between ASCA levels and mitochondrial autoantibodies (AMA) titres in PBC patients. Conclusion We conclude that ASCA are common in patients with PBC.

• 出版日期2008-7