Xenopus paraxial protocadherin inhibits Wnt/beta-catenin signalling via casein kinase 2 beta

作者：Kietzmann Anja; Wang Yingqun; Weber Dominik; Steinbeisser Herbert^*

来源：EMBO Reports, 2012, 13(2): 129-134.

DOI：10.1038/embor.2011.240

• CK2
• PAPC
• protocadherin
• Wnt pathway
• Xenopus

Xenopus paraxial protocadherin (PAPC) regulates cadherin-mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/beta-catenin pathway. The intracellular domain of PAPC interacts with casein kinase 2 beta (CK2 beta), which is part of the CK2 holoenzyme. The CK2 alpha/beta complex stimulates Wnt/beta-catenin signalling, and the physical interaction of CK2 beta with PAPC antagonizes this activity. By this mechanism, PAPC restricts the expression of Wnt target genes during gastrulation. These experiments identify a novel function of protocadherins as regulators of the Wnt pathway.

• 出版日期2012-1