Analgesic use during pregnancy and risk of infant leukaemia: A Children's Oncology Group study

作者：Ognjanovic S^*; Blair C; Spector L G; Robison L L; Roesler M; Ross J A

来源：British Journal of Cancer, 2011, 104(3): 532-536.

DOI：10.1038/sj.bjc.6606046

• epidemiology
• infants
• leukaemia
• analgesics

BACKGROUND: Infant leukaemia is likely initiated in utero.
METHODS: We examined whether analgesic use during pregnancy was associated with risk by completing telephone interviews of the mothers of 441 infant leukaemia cases and 323 frequency-matched controls, using unconditional logistic regression.
RESULTS: With the exception of a reduced risk for infant acute myeloid leukaemias with non-aspirin non-steroidal anti-inflammatory drugs (NSAID) use early in pregnancy (odds ratios = 0.60; confidence intervals: 0.37-0.97), no statistically significant associations were observed for aspirin, non-aspirin NSAIDs, or acetaminophen use in early pregnancy or after knowledge of pregnancy.
CONCLUSION: Overall, analgesic use during pregnancy was not significantly associated with the risk of infant leukaemia. British Journal of Cancer (2011) 104, 532-536. doi:10.1038/sj.bjc.6606046 www.bjcancer.

• 出版日期2011-2-1