alpha-Synuclein: The Long Distance Runner

作者：George Sonia; Rey Nolwen L; Reichenbach Nicole; Steiner Jennifer A; Brundin Patrik^*

来源：Brain Pathology, 2013, 23(3): 350-357.

DOI：10.1111/bpa.12046

• alpha-Synuclein
• Lewy pathology
• Parkinson's disease
• prion disease
• prion-like aggregation
• templated misfolding

Parkinson's disease is characterized by -synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak etal described the spatial and temporal spread of -synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that -synuclein can transfer from cell to cell. In this review, we highlight the involvement of -synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of -synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of -synuclein and focus our review on the long-distance axonal transport of -synuclein along neurons.

• 出版日期2013-5