NEW THIAZOLIDINE-4-ONES OF FERULIC ACID WITH ANTIOXIDANT POTENTIAL

作者：Wolszleger Maria; Stan Catalina Daniela; Panzariu Andreea; Jitareanu Alexandra; Profire Lenuta^*

来源：Farmacia, 2015, 63(1): 150-154.

• ferulic acid
• thiazolidin-4-one
• antioxidant activity

New thiazolidine-4-one derivatives of ferulic acid have been synthesized in one step ("one-pot") by cyclization of ferulic acid hydrazide with different aromatic aldehydes and mercaptoacetic acid. The structure of the synthesized compounds was proved by infrared (IR) and nuclear magnetic resonance (H-1-NMR) spectroscopy. The in vitro antioxidant potential of the synthesized compounds was evaluated according to the 1,1-dipheny1-2-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays. Some of synthesized compounds showed a good antioxidant activity which supports the favourable influence of the structural modulation on the antioxidant effects of the ferulic acid.

• 出版日期2015-2