Adiposity and risks of colorectal and small intestine cancer in Chinese adults: a prospective study of 0.5 million people

作者：Pang, Yuanjie; Kartsonaki, Christiana^*; Guo, Yu; Chen, Yiping; Yang, Ling; Bian, Zheng; Bragg, Fiona; Millwood, Iona Y.; Mao, Enke; Li, Yilei; Shi, Liya; Chen, Junshi; Li, Liming; Holmes, Michael V.; Chen, Zhengming

来源：British Journal of Cancer, 2018, 119(2): 248-250.

DOI：10.1038/s41416-018-0124-8

BACKGROUND: Uncertainty remains about the associations of adiposity with intestinal cancer in China and by its anatomical subtype. @@@ METHODS: The prospective China Kadoorie Biobank recorded 3024 incident cases of colorectal (CRC) and 143 cases of small intestine (SIC) cancer during a 10-year follow-up among 509 568 participants without prior cancer at baseline. Cox regression was used to estimate adjusted hazard ratios (HRs) for specific cancers associated with adiposity. @@@ RESULTS: Overall mean body mass index (BMI) was 23.7 kg/m(2). BMI was positively associated with CRC (HR per SD 1.10 [95% CI 1.06-1.14]), colon (1.13 [1.07-1.18]), and rectal (1.07 [1.02-1.13]) cancer. For waist circumference, the corresponding HRs per SD were 1.14 (1.10-1.18), 1.18 (1.13-1.24), and 1.11 (1.05-1.16), respectively. The adjusted HRs were somewhat greater in men than women. Adiposity was positively, but non-significantly, associated with SIC risk. @@@ CONCLUSIONS: Among relatively lean Chinese adults, adiposity was associated with risks of colon and rectal cancer, with the associations somewhat stronger in men than women.

• 出版日期2018-7-17
• 单位北京大学; 中国医学科学院北京协和医院; 海南医学院; 北京协和医学院; 国家食品安全风险评估中心