A Convenient Synthesis of 1-Aryl- and 2-Aryl-Substituted Indazolones via Intramolecular C-N Coupling Promoted by KOt-Bu

作者:Wang, Wei-juan; Chen, Jia-hua; Chen, Zi-cong; Zeng, Yu-feng; Zhang, Xue-jing*; Yan, Ming*; Chan, Albert S. C.
来源:Synthesis (Germany), 2016, 48(20): 3551-3558.
DOI:10.1055/s-0035-1562430

摘要

A new method for the synthesis of 1-arylindazolones and 2-arylindazolones from N'-aryl-2-halobenzohydrazides promoted by KOt-Bu was developed. The difference of 2-halogen substituent exerted a significant effect on the distribution of the products. Two distinct reaction pathways are proposed for the generation of 1-arylindazolones and 2-arylindazolones, respectively.