An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoli ne-1,3(2H)-diones and Their Antimicrobial Activity

Sakram B<sup>*</sup>; Ravi D; Ashok K; Rambabu S; Sonyanaik B<sup>*</sup>; Kurumanna A

doi:10.1134/S1070363218040242

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An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoli ne-1,3(2H)-diones and Their Antimicrobial Activity

作者：Sakram B^*; Ravi D; Ashok K; Rambabu S; Sonyanaik B^*; Kurumanna A

来源：Russian Journal of General Chemistry, 2018, 88(4): 780-788.

DOI：10.1134/S1070363218040242

摘要

The Buchwald-Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)(4) and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, H-1 and C-13 NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.