Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

作者：Lu, Jianxin; Randell, Edward; Han, YingChun; Adeli, Khosrow; Krahn, John; Meng, Qing H.^*

来源：Clinical Biochemistry, 2011, 44(4): 307-311.

DOI：10.1016/j.clinbiochem.2010.11.004

• Methylglyoxal
• Cytokines
• Adhesion molecules
• Diabetes
• Diabetic
• Nephropathy

Objectives: To investigate the association of plasma levels of methylglyoxal (MG) and markers of inflammation/endothelial dysfunction with diabetic nephropathy (DN).
Design and methods: Plasma levels of MG, cytokines, and adhesion molecules were measured in type 2 diabetic patients (T2DM), T2DM patients with DN, and the controls.
Results: Plasma MG levels in DN were significantly higher than those in T2DM and the controls (312 +/- 135 vs. 212 +/- 73 and 312 +/- 135 vs. 147 +/- 78 nmol/L, respectively, P < 0.001). The plasma levels of MG were positively correlated with the fasting glucose, HbA1c, and urinary albumin/creatinine ratio (r = 0.754. P < 0.05). Plasma levels of IL-6, TNF-alpha, and adhesion molecules were markedly increased in DN compared to T2DM patients and the controls.
Conclusions: Increased plasma levels of MG, cytokines, and adhesion molecules are associated with DN. These markers may be useful in predicting the development of DN.

• 出版日期2011-3
• 单位温州医科大学