Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin

作者：Kitada Shingo; Fujita Shuji; Okada Yohei; Kim Shokaku; Chiba Kazuhiro^*

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(15): 4476-4479.

DOI：10.1016/j.bmcl.2011.06.004

• Hydrophobic tag
• Liquid-phase peptide synthesis
• Disulfide bond
• Cyclic peptide
• Somatostatin

Hydrophobic tag-assisted liquid-phase peptide synthesis technique and disulfide bond formation have been well-combined, leading to the efficient and practical preparation of a growth hormone-inhibiting peptide somatostatin. Intramolecular disulfide bond formation has successfully been carried out even under relatively high concentrations, enabling the effective peptide modifications in preparative scale.

• 出版日期2011-8-1