A reversed phase/hydrophilic interaction/ion exchange mixed-mode stationary phase for liquid chromatography

作者：Zhang, Sainan; Zhang, Feifang; Yang, Bingcheng^*; Liang, Xinmiao

来源：Chinese Chemical Letters, 2019, 30(2): 470-472.

DOI：10.1016/j.cclet.2018.04.013

• Mixed-mode
• Stationary phase
• Reversed phase liquid chromatography
• Hydrophilic interaction liquid chromatography
• Ion exchange
• Drug molecules

A reversed phase (RP)/hydrophilic interaction (HILIC)/ion exchange (IEX) mixed tri-mode stationary phase (TMSP) has been prepared via a divergent synthesis scheme starting from propylamine on silica then by amine-epoxy reactions with 1,4-butanedioldiglycidyl ether and tertiary amines (N,N-dimethyldecylamine, DMDA). Its retention mechanism was found to follow RP/HILIC/IEX mixed-mode. The stop-flow test revealed that TMSP had good compatibility with 100% aqueous mobile phase. It demonstrated effective separation towards several kinds of compounds or drug molecules and their counterions within a single run.

• 出版日期2019-2
• 单位华东理工大学