Bone formation and osseointegration with titanium implant using granular- and block-type porous hydroxyapatite ceramics (IP-CHA)

作者：Minami Masahiko; Takechi Masaaki^*; Ohta Kouji; Ohta Akira; Ninomiya Yoshiaki; Takamoto Megumi; Fukui Akiko; Tada Misato; Kamata Nobuyuki

来源：Dental Materials Journal, 2013, 32(5): 753-760.

DOI：10.4012/dmj.2012-169

• Interconnected porous hydroxyapatite ceramics (IP-CHA)
• Titanium implant
• New bone formation

The aim of the present study was to examine whether interconnected porous hydroxyapatite ceramics (IP-CHA) could be used as bone substitute for implant treatment in reconstructive surgery. We firstly assessed if surround of the titanium surface placed into granular or block-type IP-CHA can observe new bone formation in a rabbit bone defect model. Subsequently, osseointegration and stability of titanium implant inserted into block-type IP-CHA was investigated in a rabbit onlay graft model. Direct contact between new bone and the surface of the titanium in granular- or block-type IP-CHA was found in a rabbit bone defect. Further, new bone formation was found in direct contact with the implant surface in the block-type IP-CHA in an onlay graft model, and the implant stability quotient (ISQ) values were significantly increased after surgery. Therefore, IP-CHA may be a useful material for implant treatment in reconstructive surgery strategies.

• 出版日期2013-10