Diseases of the pancreas and suicide mortality: A nationwide nested case-control study among patients with mental health disorders in Taiwan

作者：Chen Hong Ming; Chen Vincent Chin Hung; Wang Tsu Nai; Lu Mong Liang; Huang Yin Cheng; Dewey Michael E; Lee Johnny Kuang Wu; Tsai Ching Piao^*

来源：General Hospital Psychiatry, 2018, 50: 45-50.

DOI：10.1016/j.genhosppsych.2017.09.008

• Diseases of the pancreas
• Pancreatitis
• Suicide
• Mental disorders

Objective: Diseases of the pancreas, especially pancreatitis, have been implicated as possible risk factors for psychiatric illnesses, such as depression and anxiety disorder. This nested case-control study aimed to investigate the association between diseases of the pancreas and completed suicide in a psychiatric population-based study.
Methods: The case group comprised 6568 completed suicides (ICD-9: E950-E959, E980-989) patients from the national mortality database between January 1, 2002 and December 1, 2010. These cases were compared with 6568 gender-, age-, residence-, and insurance premium-matched controls. Both suicide and non-suicide study patients were drawn from a group with previous psychiatric diagnoses. The risk of suicide among patients with diseases of the pancreas was analyzed using a conditional logistic regression model that controlled for alcohol-related disorder, drug dependence, schizophrenia, depressive disorder, bipolar disorder, anxiety disorder, Charlson comorbidity score, and outpatient visits.
Results: Disease of the pancreas was an independent risk factor for psychiatric patients who had completed suicide when adjusted for clinical and other comorbid factors. Among these covariates, alcohol-related disorders partially mediate the suicide risk among patients with disease of the pancreas, and mental disorders may not mediate this suicide risk.
Conclusions: Diseases of the pancreas were associated with increased risk of completed suicide after controlling for potential confounding factors.

• 出版日期2018-2
• 单位长春大学