Drug-induced skin toxicity and clinical nursing of VitK cream on colorectal cancer patients

作者：Li Ai Min; Miao Jin Hong; Liu Hui; Ma Yao Zhen; Sun Zhen Chang^*

来源：Pakistan Journal of Pharmaceutical Sciences, 2015, 28(4): 1499-1503.

• Vitamin K1
• Cetuximab
• skin toxicity
• nursing

To discuss the impact of 0.1% vitamin K1 (VitK(1)) cream on cetuximab-induced skin toxicity for colorectal cancer patients. 60 colorectal cancer patients with cetuximab therapy after hospitalization, were divided into experimental group (Ward A) and control group (Ward B) according to personnel sequential number, with 30 cases in each group. Routine nursing was implemented on control group. For experimental group, on the routine nursing basis, 0.1% VAtK1 cream was smeared on face, neck, chest, back and nail (toenail) edge with three times one day at the application of cetuximab day. After cetuximab applied in 8 weeks, both skin itch and dry skin for patients in experimental group were significantly improved compared those in control group, showing statistically significant difference (W=708.000, P=0.001: W=662. 500, P=0.000). 0.1% VitK(1) cream was conducive to improve both skin itch and dry skin symptoms in the cetuximab-induced skin toxicity for colorectal cancer patients.

• 出版日期2015-7
• 单位郑州大学