Nasal and systemic inflammatory profile after short term smoking cessation

作者：Machado Rodrigues Fernanda Maria; Ramos Dionei; Xavier Rafaella Fagundes; Ito Juliana Tiyaki; de Souza Alcirene Policarpo; Fernandes Romulo Araujo; Cecchini Rubens; Rossi e Silva Renata Calciolari; Macchione Mariangela; de Toledo Arruda Alessandra Choqueta; Guarnier Flavia Alessandra; Cipulo Ramos Ercy Mara

来源：Respiratory Medicine, 2014, 108(7): 999-1006.

DOI：10.1016/j.rmed.2014.04.020

• Inflammation
• Mucociliary clearance
• Smoking cessation
• Smoking

Introduction: Smoking cessation promotes health benefits and, despite cigarette smoking be an important pro inflammatory stimulus, there are few studies concerning the nasal and systemic inflammation; as well as the mucociliary clearance behavior in smokers after short period of smoking cessation.
Aim: To evaluate the nasal and systemic inflammatory markers and mucociliary clearance behavior after 30 days of cigarette smoking abstinence.
Methods: Twenty-five smokers were included and divided into two groups: abstinent smokers (n = 14) and current smokers (n = 11). Tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-8 and IL-10 were measured on nasal lavage and blood serum samples by ELISA at baseline and after 30 days. The mucociliary clearance, exhaled carbon monoxide (exCO) and carboxyhemoglobin (HbCO) were also measured at the same moments.
Results: There was a decrease of TNF-alpha level only in blood serum at 30 days of abstinence compared to current smokers. The mucociliary clearance improved and there was a reduction in exCO and HbCO (p < 0.05 for all) after 30 days of smoking cessation.
Conclusion: The short term smoking abstinence decreased systemic inflammation and improved nasal mucociliary clearance, despite not having changed the nasal inflammation.

• 出版日期2014-7