Development and utilization of a bovine type I collagen microfibril model

作者：Brown Eleanor M^*

来源：International Journal of Biological Macromolecules, 2013, 53: 20-25.

DOI：10.1016/j.ijbiomac.2012.10.029

• Bovine type I collagen
• Microfibril model
• Crosslinks

The structure of fibrous collagen, a long triple helix that self-associates in a staggered array to form a matrix of fibrils, fibers and fiber bundles, makes it uniquely suitable as a scaffold for biomaterial engineering. A major challenge for this application is to stabilize collagen structure by means that are acceptable for the end use. The bovine type I collagen microfibril model, built by computer assisted modeling, comprised of five right-handed triple helices in a left-handed super coil containing gap and overlap regions as well as the nonhelical telopeptides is a tool for predicting or visualizing chemistry to stabilize the matrix, insert an active agent, or otherwise modify collagen. Published by Elsevier B.V.

• 出版日期2013-2