A New Concept in Treatment of Burn Injury Controlled Slow-Release Granulocyte-Monocyte Colony-Stimulating Factor Chitosan Gel System

作者：Simsek Serife; Canter Halil Ibrahim^*; Konas Ersoy; Korkusuz Petek; Demir Devrim; Oner Filiz; Unsal Ibrahim; Mavili Mehmet Emin

来源：Annals of Plastic Surgery, 2011, 67(6): 583-588.

DOI：10.1097/SAP.0b013e31822af865

• controlled slow-release
• GM-CSF
• chitosan
• burn

Objective: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing.
Material and Methods: In vivo effect of controlled slow-release GM-CSF from chitosan gel on burn wound healing was evaluated on 18 Wistar-Albino rats, weighing between 250 and 300 g. They were randomly divided into 3 groups; (1) burned only group (n = 6), (2) burned + chitosan group (n = 6), (3) burned + chitosan + GM-CSF group (n = 6). Wound area was measured macroscopically. Hematoxylin and eosin and Masson's trichrome stained sections were evaluated for wound healing and tissue response to the polymer.
Results: The best healing process was observed with the controlled slow-release GM-CSF-applied group (group 3) in which the wound area was significantly narrowed.
Conclusion: The study demonstrated the positive contribution of the single-dose controlled slow-release GM-CSF from chitosan gel on burn wound healing.

• 出版日期2011-12