Design and Synthesis of 3-Substituedmethylenethiochroman-4-ones as Anticancer Agents

作者：Ma Zheng yue; Zhang Xing hua; Li Chun na; Zheng Ya jun; Yang Geng liang^*; Wang Shi kui; He Yang

来源：Chemical Research in Chinese Universities, 2011, 27(5): 787-791.

• Anticancer activity
• 3-Chloromethylene
• Thiochromanone

A series of 3-substituedmethylenethiochroman-4-ones was designed and synthesized, and their structures were confirmed by (1)H NMR, (13)C NMR, MS, IR, UV and elemental analysis. The results of their anticancer activity studies show that almost all 3-chloromethylenethiochroman-4-ones exhibit high anticancer activities and their activities are all better than reference cisplatin. Their IC(50) against cancer cells is in a range of 0.80-9.17 mu g/mL. Thus they could be promising candidates for anticancer drugs. However, compound 5 has no activity against cancer cells, thus chloromethylene at the 3 position of thiochroman-4-ones seems to play an important role in observed anticancer activities.

• 出版日期2011-9
• 单位河北大学