2,6,8-Triaryl-3-iodoquinolin-4(1H)-ones as Substrates for the Synthesis of 2,3,6,8-Tetraarylquinolin-4(1H)-ones and the 2-Substituted 4,6,8-Triaryl-1H-furo[3,2-c]quinolines

作者：Mphahlele Malose J^*

来源：Journal of Heterocyclic Chemistry, 2016, 53(5): 1378-1385.

DOI：10.1002/jhet.2018

The 2,6,8-triaryl-3-iodoquinolin-4(1H)-ones derived from the 2,6,8-triarylquinolin-4(1H)-ones were found to undergo Suzuki-Miyaura cross-coupling with arylboronic acids to afford the corresponding 2,3,6,8-tetraarylquinolin-4(1H)-ones. Sonogashira cross-coupling of the 2,6,8-triaryl-3-iodoquinolin-4 (1H)-ones with terminal acetylene in DMF-water (4: 1, v/v) in the presence of triethylamine, on the other hand, afforded the 2-substituted 4,6,8-triaryl-1H-furo[3,2-c]quinolines in a single-pot operation.

• 出版日期2016-9