Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active N-phthaloyl Valine Moieties in the Hepatic Cytochrome P-450 System in Male Rats

作者：Hassan Hammed H A M^*; El Banna Sabah G; Elhusseiny Amel F; Mansour El Sayed M E

来源：Molecules, 2012, 17(7): 8255-8275.

DOI：10.3390/molecules17078255

• aramide nanoparticles
• thermal analysis
• valine
• cytochrome P-450 enzymes
• TBARS

We report the synthesis of aramide nanoparticles containing a chiral N-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P-450, amidopyrene N-demethylase, aniline-4-hyroxylase and induced the hepatic content of cytochrome b5 and nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome C-reductase. Polymers were obtained as well-separated spherical nanoparticles while highly aggregated particles via H-bonding organization of the aramide-containing pyridine led to a thin layer formation. The effects of the nanoparticles and CCl4 on enzyme activities and thiobarbituric acid reactive substances (TBARS) levels of male rat liver were studied. Pretreatments of rats with the polyamides prior to the administration of CCl4 decreased the hepatic content of the tested enzymes. Doses reduced the toxic effects exerted by (center dot CCl3) upon the liver through inhibition of the cytochrome P-450 system. Inhibition of such metabolizing enzymes could reduce the carcinogenic effects of chemical carcinogens.

• 出版日期2012-7